Education & Experience

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• KAUST, Mass Spectrometry Specialist, 2025–Present

• KAUST, Postdoc, 2020–2025

• DS Bio & Nanotech, Senior Scientist, DNA Barcoding, 2019–2020

• MABxience, Trainee, Rituximab, León–Spain, 2018

• AbdiBio Biopharmaceuticals, Analyst, Monoclonal Antibodies, Istanbul, 2017–2019

• TU Munich, PhD, Medical School, 2013–2017

• Marmara University, MSc, Bioengineering, 2010–2012

 

Research Project 

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Mass spectrometry (MS) is a critical tool for uncovering disease-associated changes in organelles, particularly when mutations affect proteins localized to specific subcellular compartments. Since organelles such as the endoplasmic reticulum (~10%) and lysosomes (~3%) comprise only a small portion of total cellular content, their specific molecular alterations are often masked in whole-cell analyses. By enabling high-resolution profiling of proteins, metabolites, and lipids from isolated organelles, MS provides essential insight into compartment-specific dysfunction in inherited metabolic diseases.

Lab projects rely heavily on multi-omics profiling at both cellular and subcellular levels, analyzing samples from cultured cells, tissues, and patient-derived fluids, with a focus on proteomics and metabolomics.

The mass spectrometry specialist operates a diverse set of advanced MS platforms, including the Bruker timsTOF Pro, IDX Orbitrap, IQ-X Orbitrap, triple quadrupole, and GC-MS systems. Responsibilities include developing targeted analysis methods, processing and interpreting data using tools such as Compound Discoverer, LipidSearch, MetaboScape, and TraceFinder, and maintaining custom in-house spectral libraries to support high-quality data generation.

Additionally, isotope tracing experiments are used to monitor the dynamic flow of metabolites across organelles, allowing for the reconstruction of disrupted metabolic pathways. These integrated approaches provide deep, mechanistic insights into subcellular metabolism and serve as a foundation for hypothesis-driven investigations into organelle dysfunction in monogenic diseases.

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Fun Facts

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Fueled by books, movies, and an unquestionable loyalty to cats. When not working with mass spectrometers, I am usually relaxing with my favorite feline companions—reading a good book or watching a movie.